The results determine tiagabine was effective in treating GABA. The total number of participants was 266, and the ratio was 134:132 in favor of the placebo group. The study took eight weeks and involved a control group and the one administered with 4-16 milligrams of the medication daily.
It is a GABA reuptake inhibitor used in patients dealing with a generalized anxiety disorder. The alterations of GABA and glutamate levels could deliver anxiolytic benefits for the user.Īnother research we found discusses the effectiveness of tiagabine. The findings of the research include that the GABAergic system and its impairment plays a possible role in developing SAD. The researchers established the baseline and then administered levetiracetam as a treatment for SAD. The idea of the study was to assess the role of glutamine, glutamate, and GABA in these disorders. Although it is an animal study, it is another proof of the capability of this amino acid to lower anxiety.Ī study on ten patients that had social anxiety disorder was published in 2017 in the United States. That is how it is possible to alter experimental anxiety in these animals. The conclusion is that GABA produced by their bodies interacts with GABA-receptors in the posterior hypothalamus. The research involved training male rats with various punishment intensities to monitor their anxiety levels. That is how GABA manages to ensure the person feels calmer and more composed.Īn animal study conducted in 1989 focused on rats and the capability of GABA receptors to regulate experimental anxiety in these animals. Since this substance is an inhibitory transmitter, it has the task of decreasing neuron activity. The purpose of medications is nothing else than boosting GABA and its effectiveness in the brain. That is because these drugs interact with the same receptors as gamma-aminobutyric acid. All that makes a loop that repeats itself and eventually leads to anxiety and depression disorders.Īnother interesting hypothesis presents the idea that GABA has the same effect as Librium or Valium. That is what leads to increased emotions, which increases stress hormones. Scientists assume that the GABAergic system is behind major depressive disorders.Īccording to the explanation of this hypothesis, frequent stress decreases GABA in the brain. You can find comprehensive research on the participation of GABA in managing anxiety and depression symptoms. Let's take a look at the studies to support these claims with evidence. GABA can also be helpful in lowering anxiety and depression symptoms and boosting cognitive performance. That is why promoting an optimal sleep pattern is among the main benefits of gamma-aminobutyric acid. Since glutamate is a neurotransmitter that’s considered excitatory, GABA helps to regulate relaxation and activation times. The researchers explain that it stands on the opposite part of the scale to glutamate. GABA comes with a wide range of potential benefits. These foods include veggies, fruits, red wine, and teas. However, some foods are capable of affecting GABA production in the human body. You can't find GABA in food sources, which means that the diet doesn't affect the production of this aminobutyric acid. The human body produces GABA on its own, but you can often find it in various health supplements. GABA is a neurotransmitter, which is a substance responsible for transferring information between cells. Today, scientists pinpoint that approximately 540% of brain synaptic processing involves GABA. It is interesting to note that scientists only understood the importance of gamma-aminobutyric acid for the functioning of the human brain several decades ago.
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